Sixteen-year-old Thomas wakes up with no memory in the middle of a maze and realizes he must work with the community in which he finds himself if he is to escape.
After surviving horrific conditions in the Maze, Thomas is entrapped, along with nineteen other boys, in phase two of WICKED's experiment designed to observe their responses and gather data believed to be essential for the survival of the human race.
As the third Trial draws to a close, Thomas and some of his cohorts manage to escape from WICKED, their memories having been restored, only to face new dangers as WICKED claims to be trying to protect the human race from the deadly FLARE virus.